Skip to main content

Molecular “Fingerprinting” Now 100 Times Faster With Raman Spectroscopy




Researchers at the University of Tokyo have achieved a 100-fold increase in the measurement rate of Raman spectroscopy, advancing its application in biomedical diagnostics and materials analytics.

This innovation was enabled by combining coherent Raman spectroscopy, a specially designed ultrashort pulse laser, and time-stretch technology, offering new possibilities for high-throughput, label-free chemical imaging.

Breakthrough in Raman Spectroscopy Speed

Scientists have successfully increased the measurement rate of Raman spectroscopy, a widely used technique for identifying molecules, by 100 times. Researchers Takuma Nakamura, Kazuki Hashimoto, and Takuro Ideguchi from the Institute for Photon Science and Technology at the University of Tokyo achieved this breakthrough. Raman spectroscopy is commonly used to measure the “vibrational fingerprint” of molecules, which helps to identify them.

This significant improvement addresses a long-standing limitation in the technique’s speed, opening doors to advancements in fields that depend on rapid molecular and cellular identification, such as biomedical diagnostics and material analysis. The research was published on October 22 in the journal Ultrafast Science.




Expanding Applications in Science

Raman spectroscopy plays a crucial role in both basic and applied sciences by identifying various types of molecules and cells. When a laser beam interacts with molecules, it causes vibrations and rotations in the molecular bonds, resulting in a shift in the light’s frequency. This shift, known as the scattering spectra, forms the unique “vibrational fingerprint” of each molecule.

“Measurement is the foundation of science,” says Ideguchi, the principal investigator of the study, “and as such, we strive to achieve the highest performance in our measurement systems. Particularly, we are dedicated to pushing the boundaries of optical measurements.”

Enhancing Optical Measurements

As Raman spectroscopy is a widely used measurement technique, there have been many attempts to improve it. One of its major limiting factors is its measurement rate, making it unable to “keep up” with the speed of changes in some chemical and physical reactions. The team set to improve the measurement rate by building a system from scratch.

“I had been contemplating this idea for over ten years without being able to start the project,” says Ideguchi. “It was the new, optimal laser system we developed a few years ago that finally made progress possible.”

Technological Innovation and Future Visions

Leveraging their expertise in optics and photonics, the researchers combined three ingredients: coherent Raman spectroscopy, a version of Raman spectroscopy that produces stronger signals than conventional, spontaneous Raman spectroscopy, a specifically designed ultrashort pulse laser, and time-stretch technology using optical fibers. As a result, they achieved a 50MSpectra/s (megaspectra per second) measurement rate, a 100-fold increase compared to the fastest measurement of 50kSpectra/s (kilospectra per second) so far. Ideguchi describes the wide-ranging potential of this improvement.

“We aim to apply our spectrometer to microscopy, enabling the capture of 2D or 3D images with Raman scattering spectra. Additionally, we envision its use in flow cytometry by combining this technology with microfluidics. These systems will enable high-throughput, label-free chemical imaging and spectroscopy of biomolecules in cells or tissues.”

Website: International Research Awards on High Energy Physics and Computational Science.

#HighEnergyPhysics#ParticlePhysics#QuantumPhysics#AstroparticlePhysics#ColliderPhysics
#HiggsBoson#LHC#QuantumFieldTheory#NeutrinoPhysics#PhysicsResearch#ComputationalScience
#DataScience#ScientificComputing#NumericalMethods#HighPerformanceComputing
#MachineLearningInScience#BigData#AlgorithmDevelopment#SimulationScience#ParallelComputing

Visit Our Website : hep-conferences.sciencefather.com
Nomination Link : https://hep-conferences.sciencefather.com/award-nomination/?ecategory=Awards&rcategory=Awardee
Registration Link : hep-conferences.sciencefather.com/award-registration/
Member Link : hep-conferences.sciencefather.com/conference-membership/?ecategory=Membership&rcategory=Member
Awards-Winners : hep-conferences.sciencefather.com/awards-winners/
Contact us : contact@sciencefather.com


Get Connected Here:
==================
Social Media Link
Twitter : x.com/Psciencefather
Pinterest : in.pinterest.com/physicsresearchorganisation
Blog : physicscience23.blogspot.com
Instagram : www.instagram.com/victoriaanisa1
YouTube :www.youtube.com/channel/UCzqmZ9z40uRjiPSr9XdEwMA

Comments

Post a Comment

Popular posts from this blog

Physicists observe a new form of magnetism for the first time

MIT physicists have demonstrated a new form of magnetism that could one day be harnessed to build faster, denser, and less power-hungry " spintronic " memory chips. The new magnetic state is a mash-up of two main forms of magnetism: the ferromagnetism of everyday fridge magnets and compass needles, and antiferromagnetism, in which materials have magnetic properties at the microscale yet are not macroscopically magnetized. Now, the MIT team has demonstrated a new form of magnetism , termed "p-wave magnetism." Physicists have long observed that electrons of atoms in regular ferromagnets share the same orientation of "spin," like so many tiny compasses pointing in the same direction. This spin alignment generates a magnetic field, which gives a ferromagnet its inherent magnetism. Electrons belonging to magnetic atoms in an antiferromagnet also have spin, although these spins alternate, with electrons orbiting neighboring atoms aligning their spins antiparalle...
Post a Comment
Read more

new research in qauntum physics

         VISIT:https: //hep-conferences.sciencefather.com/          N ew research in  qauntum physics.                                                    Alphabet Has a Second, Secretive Quantum Computing Team Recent research in quantum physics includes the development of quantum computers, which are expected to be much more powerful than conventional computers and could revolutionize many aspects of technology, such as artificial intelligence and cryptography. Other research includes the development of quantum sensors for a variety of applications, including medical diagnostics, and the study of quantum entanglement and its potential to enable quantum computing and secure communication. Additionally, research is being conducted into the applications of quantum mechanics in materials science, such as unde...
Post a Comment
Read more

Physicists Catch Light in 'Imaginary Time' in Scientific First

For the first time, researchers have seen how light behaves during a mysterious phenomenon called 'imaginary time '. When you shine light through almost any transparent material, the gridlock of electromagnetic fields that make up the atomic alleys and side streets will add a significant amount of time to each photon's commute. This delay can tell physicists a lot about how light scatters, revealing details about the matrix of material the photons must navigate. Yet until now, one trick up the theorist's sleeve for measuring light's journey invoking imaginary time has not been fully understood in practical terms. An experiment conducted by University of Maryland physicists Isabella Giovannelli and Steven Anlage has now revealed precisely what pulses of microwave radiation (a type of light that exists outside the visible spectrum) do while experiencing imaginary time inside a roundabout of cables. Their work also demonstrates how imaginary numbers can describe a ver...
Post a Comment
Read more